新生儿促甲状腺素（TSH）筛查作为监测亚美尼亚碘营养状况的工具。

Neonatal thyrotropin (TSH) screening as a tool for monitoring iodine nutrition in Armenia.

机构信息

Department of Endocrinology, Yerevan State Medical University, Yerevan, Armenia.

School of Medicine, University of California, Irvine, United States.

出版信息

Eur J Clin Nutr. 2019 Jun;73(6):905-909. doi: 10.1038/s41430-018-0298-4. Epub 2018 Aug 31.

DOI:10.1038/s41430-018-0298-4

PMID:30171226

Abstract

BACKGROUND

Neonatal thyrotropin (TSH) is influenced not only by the infant's own thyroid function, but also by maternal thyroid status, and can thus provide a general index of thyroid health in the community.

METHODS

In 2012, the Republic of Armenia implemented a program of universal neonatal hypothyroidism screening by means of measuring the serum TSH level. The Arabkir Medical Center in Yerevan, Armenia, has maintained records of neonatal TSH screening data comprising nearly 100% of all births in Armenia from 2012 through 2016. We analyzed these data to determine the frequency of neonatal TSH levels higher than the cut point of 5 mIU/L, indicative of sufficient iodine nutrition status, and to detect any time dependence over years or regional variation.

RESULTS

A total of 127,177 records from 2012 to 2016 were included. The geographic distribution of neonatal TSH records was reflective of the population of Armenia; the national percentage of records over 5 mIU/L ranged from a high of 2.88% in 2012 to a low of 1.71% in 2016. Minimal regional variation was noted, from a 2012-2016 cumulative high of 2.93% of records over 5 mIU/L in Shirak province to a low of 0.95% in the Vayots Dzor province.

CONCLUSIONS

From all years and from all regions, values were consistently and uniformly below the cut point of 5 mIU/L. These results show no evidence of iodine deficiency in Armenia, and suggest that neonatal TSH may be a useful tool for monitoring iodine nutrition in Armenia.

摘要

背景

新生儿促甲状腺素（TSH）不仅受婴儿自身甲状腺功能的影响，还受母体甲状腺状况的影响，因此可以提供社区甲状腺健康的一般指标。

方法

2012 年，亚美尼亚共和国实施了一项普遍的新生儿甲状腺功能减退症筛查计划，通过测量血清 TSH 水平。亚美尼亚埃里温的 Arabkir 医疗中心保存了 2012 年至 2016 年期间几乎涵盖亚美尼亚所有新生儿 TSH 筛查数据的记录。我们分析了这些数据，以确定 TSH 水平高于 5 mIU/L 的新生儿比例，这表明碘营养状况充足，并发现任何随时间的变化，包括多年间或地区间的变化。

结果

纳入了 2012 年至 2016 年的 127177 份记录。新生儿 TSH 记录的地理分布反映了亚美尼亚的人口分布；全国 TSH 记录超过 5 mIU/L 的比例从 2012 年的 2.88%的高点到 2016 年的 1.71%的低点波动。地区间差异很小，2012 年至 2016 年期间，Shirak 省的 TSH 记录超过 5 mIU/L 的比例最高，达到 2.93%，而 Vayots Dzor 省的比例最低，为 0.95%。