Faculty of Experimental Sciences, Universidad Francisco de Vitoria, UFV, 28223 Pozuelo de Alarcón, Madrid, Spain; Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, 08003 Barcelona, Spain.
Institute of Neurosciences, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.
Biochem Pharmacol. 2018 Nov;157:43-50. doi: 10.1016/j.bcp.2018.08.040. Epub 2018 Aug 30.
A growing body of evidence suggests the existence of biochemical and functional interactions between the endocannabinoid and orexin systems. Cannabinoid and orexin receptors have been shown to form heterodimers in agreement with the overlapping distribution of both receptors in several brain areas, and the activation of common intracellular signaling pathways, such as the MAP kinase cascade. The activation of orexin receptors induces the synthesis of the endocannabinoid 2-arachidonoyl glycerol suggesting that the endocannabinoid system participates in some physiological functions of orexins. Indeed, functional interactions between these two systems have been demonstrated in several behavioral responses including nociception, reward and food intake. The present review is focused on the latest developments in cannabinoid-orexin cross-modulation and the implications of this interesting interaction.
越来越多的证据表明内源性大麻素系统和食欲素系统之间存在生化和功能相互作用。大麻素和食欲素受体已被证明可以形成异二聚体，这与两种受体在几个脑区的重叠分布以及共同的细胞内信号通路（如 MAP 激酶级联）的激活一致。食欲素受体的激活诱导内源性大麻素 2-花生四烯酰甘油的合成，表明内源性大麻素系统参与了食欲素的一些生理功能。事实上，这两个系统之间的功能相互作用已在包括痛觉、奖赏和摄食在内的几种行为反应中得到证实。本综述重点介绍了大麻素-食欲素交叉调制的最新进展及其有趣相互作用的意义。
