Bondurand Nadege, Dufour Sylvie, Pingault Veronique
Laboratory of Embryology and Genetics of Congenital Malformations, INSERM U1163, Institut Imagine, Paris, France; Paris Descartes-Sorbonne Paris Cité University, Institut Imagine, Paris, France.
INSERM, U955, Equipe 06, Créteil 94000, France; Université Paris Est, Faculté de Médecine, Créteil 94000, France.
Dev Biol. 2018 Dec 1;444 Suppl 1:S156-S169. doi: 10.1016/j.ydbio.2018.08.014. Epub 2018 Aug 30.
The endothelin system is a vertebrate-specific innovation with important roles in regulating the cardiovascular system and renal and pulmonary processes, as well as the development of the vertebrate-specific neural crest cell population and its derivatives. This system is comprised of three structurally similar 21-amino acid peptides that bind and activate two G-protein coupled receptors. In 1994, knockouts of the Edn3 and Ednrb genes revealed their crucial function during development of the enteric nervous system and melanocytes, two neural-crest derivatives. Since then, human and mouse genetics, combined with cellular and developmental studies, have helped to unravel the role of this signaling pathway during development and adulthood. In this review, we will summarize the known functions of the EDN3/EDNRB pathway during neural crest development, with a specific focus on recent scientific advances, and the enteric nervous system in normal and pathological conditions.
内皮素系统是脊椎动物特有的创新系统，在调节心血管系统、肾脏和肺部生理过程以及脊椎动物特有的神经嵴细胞群及其衍生物的发育中发挥着重要作用。该系统由三种结构相似的21个氨基酸的肽组成，这些肽结合并激活两种G蛋白偶联受体。1994年，Edn3和Ednrb基因敲除揭示了它们在肠神经系统和黑素细胞（两种神经嵴衍生物）发育过程中的关键功能。从那时起，人类和小鼠遗传学，结合细胞和发育研究，有助于揭示该信号通路在发育和成年期的作用。在这篇综述中，我们将总结EDN3/EDNRB通路在神经嵴发育过程中的已知功能，特别关注最近的科学进展，以及正常和病理条件下的肠神经系统。
