Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany; German Center for Diabetes Research (DZD), 72076 Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, 72076 Tübingen, Germany.
Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany; School of Psychology, University of Birmingham, B15 2TT Birmingham, UK.
Psychoneuroendocrinology. 2019 Jan;99:1-7. doi: 10.1016/j.psyneuen.2018.08.028. Epub 2018 Aug 23.
Impaired sleep quality and sleep loss compromise glucose homeostasis and metabolic function, but the mechanisms linking sleep and metabolic health are largely unclear. In order to gain insight into the relevance of specific electrophysiological sleep characteristics for metabolic control, we assessed the acute effect on glucose homeostasis as well as energy intake and expenditure of enhancing slow oscillatory activity, a hallmark of slow-wave sleep, by closed-loop auditory stimulation in healthy men. Twenty-two young, normal-weight men underwent an oral glucose tolerance test (oGTT), indirect calorimetry and the assessment of ad-libitum breakfast intake in the morning after nocturnal sleep with or without auditory stimulation in phase with the ongoing rhythmic occurrence of slow oscillation up-states during 210 min of slow-wave sleep in the first night-half. Stimulation vs. no stimulation strongly increased slow oscillatory activity without changing overall sleep structure, but did not alter fasting or oGTT-stimulated measures of glucose homeostasis. Food intake and energy expenditure were likewise comparable between conditions. Findings indicate that in healthy humans electrophysiological sleep quality is tuned to allow for optimal metabolic control. Future studies should investigate the potential of sleep stage-specific interventions to enhance metabolic control and well-being in patients with metabolic ailments.
睡眠质量受损和睡眠缺失会影响葡萄糖稳态和代谢功能，但睡眠与代谢健康之间的联系机制在很大程度上还不清楚。为了深入了解特定的电生理睡眠特征与代谢控制的相关性，我们评估了在健康男性中通过闭环听觉刺激增强慢波振荡活动（慢波睡眠的标志）对葡萄糖稳态以及能量摄入和消耗的急性影响。22 名年轻、体重正常的男性在夜间睡眠后进行了口服葡萄糖耐量试验（oGTT）、间接热量测定和随意早餐摄入量评估，在第一个夜间睡眠的前半段，听觉刺激与慢波睡眠中慢波上相的持续节律性发生同步，持续 210 分钟。与没有刺激相比，刺激强烈增加了慢波振荡活动，而不会改变整体睡眠结构，但不会改变空腹或 oGTT 刺激的葡萄糖稳态测量值。在两种情况下，食物摄入和能量消耗也相似。研究结果表明，在健康人群中，电生理睡眠质量可以进行调整，以实现最佳的代谢控制。未来的研究应探讨特定睡眠阶段干预的潜力，以增强代谢紊乱患者的代谢控制和幸福感。
