Paradiso A, Silvestrini R, Daidone M G, Coltro Campi C, Grignolio E
Basic Appl Histochem. 1986;30(2):215-20.
Tumor cellular proliferative activity was evaluated by 3H-thymidine labeling index (LI) determination in 73 lesions from 62 patients with ovarian cancers. The median LI value for the overall series was 5.8% and places this tumor type in a position of intermediate proliferative activity. In this case series, the relationship between proliferative activity and different morphologic and pathologic characteristics of the disease was analyzed. Similar median LI values were found for ascitic effusions and solid tumors and, among these, between primary tumors and metastases. No significant relation was observed between proliferative activity and histologic type, whereas a definite direct correlation was found between the kinetic variable and prognostic features such as pathologic stage and histologic grading. In fact median LI was higher for stage IV for stage I and for grade 3 than for grade 1 tumors. The strong association between tumor proliferative rate and conventional prognostic factors suggests that also on this tumor type the kinetic variable could play a role as a prognostic indicator and modulator of aggressiveness.
通过测定62例卵巢癌患者73个病灶的3H-胸腺嘧啶核苷标记指数（LI）来评估肿瘤细胞增殖活性。整个系列的LI中位数为5.8%，表明这种肿瘤类型处于中等增殖活性水平。在该病例系列中，分析了增殖活性与疾病不同形态学和病理学特征之间的关系。腹水和实体瘤的LI中位数相似，其中原发性肿瘤和转移灶之间也相似。未观察到增殖活性与组织学类型之间存在显著关系，而动力学变量与病理分期和组织学分级等预后特征之间存在明确的直接相关性。事实上，IV期、I期、3级肿瘤的LI中位数高于1级肿瘤。肿瘤增殖率与传统预后因素之间的强关联表明，在这种肿瘤类型中，动力学变量也可能作为预后指标和侵袭性调节因子发挥作用。
