Department of Systems Medicine, International Medical School, University of Rome Tor Vergata, Viale Montpellier 1, 00133 Rome, Italy.
Private practice, Viale Angelico 39, 00195 Rome, Italy.
Psychiatry Res. 2018 Nov;269:394-398. doi: 10.1016/j.psychres.2018.08.099. Epub 2018 Aug 25.
We aimed to ascertain if cholesterol levels within the reference standards for healthy non-pregnant women are a risk factor for depressive and anxiety symptoms in the immediate postpartum period. During the first week after delivery, total cholesterol levels of 120 new mothers were measured and their mood state was assessed with the Profile of Mood States (POMS). Two weeks before delivery, mothers' personal and family history of mood disturbances was assessed with the Maternal History of Mood Disturbances (MHMD) scale. Only 26 (22%) of the new mothers had normal cholesterol levels (≤200 mg/dL). Mothers with normal levels did not differ on psychometric measures from those with high levels. However, in the subgroup of mothers with normal cholesterol, those with lower levels experienced more symptoms of anxiety, depression and fatigue and scored higher on the MHMD scale. In the larger group of mothers with high cholesterol levels, history of mood disturbances and postpartum depressive and anxiety symptoms were not correlated with total cholesterol. Measuring cholesterol levels in the peripartum can be useful to identify a subgroup of women with naturally low cholesterol levels and an increased risk for postpartum depressive and anxiety symptoms.
我们旨在确定健康非孕妇的参考标准内的胆固醇水平是否是产后即刻出现抑郁和焦虑症状的一个危险因素。在分娩后的第一周，对 120 名新妈妈的总胆固醇水平进行了测量，并使用心境状态问卷（POMS）评估了她们的情绪状态。在分娩前两周，使用孕产妇心境障碍史（MHMD）量表评估了母亲个人和家庭的心境障碍史。只有 26 名（22%）新妈妈的胆固醇水平正常（≤200mg/dL）。胆固醇水平正常的母亲在心理测量指标上与高水平的母亲没有差异。然而，在胆固醇水平正常的母亲亚组中，胆固醇水平较低的母亲经历更多的焦虑、抑郁和疲劳症状，在 MHMD 量表上的得分更高。在胆固醇水平较高的较大组母亲中，心境障碍史和产后抑郁和焦虑症状与总胆固醇水平没有相关性。在围产期测量胆固醇水平可以有助于识别具有自然低胆固醇水平和产后抑郁和焦虑症状风险增加的女性亚组。
