• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗坏血酸-铜离子体系对组氨酸残基中咪唑环的选择性氧化

Selective oxidation of imidazole ring in histidine residues by the ascorbic acid-copper ion system.

作者信息

Uchida K, Kawakishi S

出版信息

Biochem Biophys Res Commun. 1986 Jul 31;138(2):659-65. doi: 10.1016/s0006-291x(86)80547-2.

DOI:10.1016/s0006-291x(86)80547-2
PMID:3017335
Abstract

In connection with the physiological actions of active oxygen species on proteins, oxidative modification of histidine residues by the autoxidation of ascorbic acid was determined and the main oxidized compound was identified. Oxidation of imidazole ring by the ascorbic acid-copper ion system was considerably site-specific and assumed to be initiated by the addition of the hydroxyl radical (.0H) at C-2 position in the imidazole ring.

摘要

关于活性氧对蛋白质的生理作用，测定了抗坏血酸自氧化对组氨酸残基的氧化修饰，并鉴定了主要的氧化产物。抗坏血酸-铜离子体系对咪唑环的氧化具有相当的位点特异性，推测是由咪唑环C-2位上的羟基自由基（·OH）加成引发的。

相似文献

1
Selective oxidation of imidazole ring in histidine residues by the ascorbic acid-copper ion system.抗坏血酸-铜离子体系对组氨酸残基中咪唑环的选择性氧化
Biochem Biophys Res Commun. 1986 Jul 31;138(2):659-65. doi: 10.1016/s0006-291x(86)80547-2.
2
Site-specific oxidation of angiotensin I by copper(II) and L-ascorbate: conversion of histidine residues to 2-imidazolones.铜（II）和L-抗坏血酸对血管紧张素I的位点特异性氧化：组氨酸残基转化为2-咪唑酮。
Arch Biochem Biophys. 1990 Nov 15;283(1):20-6. doi: 10.1016/0003-9861(90)90606-y.
3
Selective oxidation of histidine residues in proteins or peptides through the copper(II)-catalysed autoxidation of glucosone.通过葡萄糖酮的铜（II）催化自氧化对蛋白质或肽中的组氨酸残基进行选择性氧化。
Biochem J. 1992 Jul 15;285 ( Pt 2)(Pt 2):667-71. doi: 10.1042/bj2850667.
4
The role of histidine residues in the nonenzymic covalent attachment of glucose and ascorbic acid to protein.组氨酸残基在葡萄糖和抗坏血酸与蛋白质的非酶共价连接中的作用。
Free Radic Res Commun. 1991;14(4):279-87. doi: 10.3109/10715769109088957.
5
Highly site-specific oxygenation of 1-methylhistidine and its analogue with a copper (II)/ascorbate-dependent redox system.
Biochim Biophys Acta. 1990 Jun 20;1034(3):347-50. doi: 10.1016/0304-4165(90)90063-3.
6
Mechanism of the inhibition of catalase by ascorbate. Roles of active oxygen species, copper and semidehydroascorbate.抗坏血酸对过氧化氢酶的抑制机制。活性氧、铜和半脱氢抗坏血酸的作用。
J Biol Chem. 1986 Jan 25;261(3):1193-200.
7
Model studies on the metal-catalyzed protein oxidation: structure of a possible His-Lys cross-link.金属催化蛋白质氧化的模型研究：一种可能的组氨酸-赖氨酸交联结构
Chem Res Toxicol. 2004 Jan;17(1):110-8. doi: 10.1021/tx034167s.
8
Copper-catalyzed oxidation of the recombinant SHa(29-231) prion protein.铜催化重组SHa(29 - 231)朊病毒蛋白的氧化反应。
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7170-5. doi: 10.1073/pnas.121190898. Epub 2001 Jun 12.
9
Copper-catalyzed autoxidations of GSH and L-ascorbic acid: mutual inhibition of the respective oxidations by their coexistence.
Biochim Biophys Acta. 2000 May 1;1474(3):378-82. doi: 10.1016/s0304-4165(00)00034-9.
10
Vitamin C (ascorbic acid) induced hydroxyl radical formation in copper contaminated household drinking water: role of bicarbonate concentration.
Free Radic Res. 2003 Aug;37(8):901-5. doi: 10.1080/1071576031000136568.

引用本文的文献

1
Monitoring RNA dynamics in native transcriptional complexes.监测天然转录复合物中的 RNA 动态。
Proc Natl Acad Sci U S A. 2021 Nov 9;118(45). doi: 10.1073/pnas.2106564118.
2
Electrochemical sensing of histamine using a glassy carbon electrode modified with multiwalled carbon nanotubes decorated with Ag-AgO nanoparticles.使用修饰有 Ag-AgO 纳米颗粒的多壁碳纳米管的玻碳电极电化学传感组胺。
Mikrochim Acta. 2019 Oct 25;186(11):714. doi: 10.1007/s00604-019-3860-4.
3
Covalent Modification of Amino Acids and Peptides Induced by Ionizing Radiation from an Electron Beam Linear Accelerator Used in Radiotherapy.
电子束直线加速器在放射治疗中产生的离子辐射诱导的氨基酸和肽的共价修饰。
Radiat Res. 2019 May;191(5):447-459. doi: 10.1667/RR15288.1. Epub 2019 Mar 8.
4
2-Oxo-histidine-containing dipeptides are functional oxidation products.含 2-氧代组氨酸的二肽是功能性氧化产物。
J Biol Chem. 2019 Jan 25;294(4):1279-1289. doi: 10.1074/jbc.RA118.006111. Epub 2018 Nov 30.
5
Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer.铜氧化还原循环抑制 Aβ 纤维形成并促进纤维断裂，同时产生二酪氨酸 Aβ 二聚体。
Sci Rep. 2018 Nov 1;8(1):16190. doi: 10.1038/s41598-018-33935-5.
6
Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function.植物线粒体中的二价金属离子及其在与蛋白质相互作用以及氧化应激诱导的呼吸功能损伤中的作用。
Plant Physiol. 2010 Feb;152(2):747-61. doi: 10.1104/pp.109.147942. Epub 2009 Dec 14.
7
Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation.用于生物共轭的铜催化叠氮化物-炔烃环加成反应的分析与优化
Angew Chem Int Ed Engl. 2009;48(52):9879-83. doi: 10.1002/anie.200905087.
8
Histamine as a marker for hydroxyl radicals.作为羟自由基标志物的组氨酸。
Mediators Inflamm. 1995;4(5):339-43. doi: 10.1155/S0962935195000548.
9
Chemical pathways of peptide degradation. X: effect of metal-catalyzed oxidation on the solution structure of a histidine-containing peptide fragment of human relaxin.肽降解的化学途径。X：金属催化氧化对人松弛素含组氨酸肽片段溶液结构的影响。
Pharm Res. 2000 Jul;17(7):851-8. doi: 10.1023/a:1007564410491.
10
Effects of polyaminocarboxylate metal chelators on iron-thiolate induced oxidation of methionine- and histidine-containing peptides.聚氨基羧酸盐金属螯合剂对硫醇铁诱导的含蛋氨酸和组氨酸肽氧化的影响。
Pharm Res. 1996 Jun;13(6):931-8. doi: 10.1023/a:1016021716274.