Department of Pathology, CHU Habib Bourguiba, Sfax 3029, Tunisia; Sfax Medical School, University of Sfax, Sfax 3029, Tunisia.
Department of Pathology, CHU Habib Bourguiba, Sfax 3029, Tunisia; Sfax Medical School, University of Sfax, Sfax 3029, Tunisia.
Hepatobiliary Pancreat Dis Int. 2018 Aug;17(4):345-348. doi: 10.1016/j.hbpd.2018.06.008. Epub 2018 Jun 26.
The histopathological examination of cholecystectomy specimens has not been standardized with a debate concerning the routine and the selective approach. The aim of this study was to assess the information obtained from routine histopathological examination of cholecystectomy specimens.
All histopathological reports of cholecystectomy specimens between January 2003 and December 2016 were analyzed, including a clinical diagnosis of benign gallstone disease or cholecystitis.
A total of 20,584 reports were examined. The mean age of patients was 54.2 years. Patients aged more than 60 years represent 37.6% of the study population. Of all patients, 15,973 (77.6%) were females. Incidental gallbladder cancers (GBC) were present in 155 cholecystectomies specimens (0.8%). 67.1% of GBC are at T2 and T3 stage. Granulomatous cholecystitis was diagnosed in only 19 cases (0.1%). GBC were more prevalent in older patients (P < 10) and cholesterolosis was more prevalent in young patients (P < 10). There was no gender predilection for GBC (P = 0.739).
The rate of incidental gallbladder carcinoma in our study is low, yet, we found a higher proportion of T2 and T3 carcinomas stage. Granulomatous cholecystitis may need further investigations and treatments. When a selective approch of histopathological examination of cholecystectomy specimens is used, it is important to take into account that clinical parameters are significantly associated with gallbladder cancer.
胆囊切除术标本的组织病理学检查尚未标准化，存在常规检查和选择性检查方法的争议。本研究旨在评估胆囊切除术标本常规组织病理学检查获得的信息。
分析了 2003 年 1 月至 2016 年 12 月期间所有胆囊切除术标本的组织病理学报告，包括良性胆囊结石病或胆囊炎的临床诊断。
共检查了 20584 份报告。患者的平均年龄为 54.2 岁。年龄超过 60 岁的患者占研究人群的 37.6%。所有患者中，女性占 15973 例（77.6%）。在 155 例胆囊切除标本中发现了 155 例偶然胆囊癌（GBC）（0.8%）。GBC 的 67.1%处于 T2 和 T3 期。仅诊断出 19 例（0.1%）肉芽肿性胆囊炎。GBC 在老年患者中更为常见（P<0.01），胆固醇沉着症在年轻患者中更为常见（P<0.01）。GBC 无性别倾向（P=0.739）。
在我们的研究中，偶然胆囊癌的发生率较低，但我们发现 T2 和 T3 期癌的比例较高。肉芽肿性胆囊炎可能需要进一步的检查和治疗。当使用胆囊切除术标本的选择性组织病理学检查方法时，重要的是要考虑到临床参数与胆囊癌显著相关。
