Doyen V, Braun J-J, Lutz C, Khayath N, de Blay F
Clinique d'immuno-allergologie, CHU de Brugmann, université Libre de Bruxelles (ULB), 4, place Van Gehuchten, 1200 Bruxelles, Belgique.
Service de pneumologie et d'allergologie, hôpitaux universitaires de Strasbourg, pôle de pathologie thoracique, NHC, 67000 Strasbourg, France; Service ORL-CCF, hôpital de Hautepierre, hôpitaux universitaires de Strasbourg, 67000 Strasbourg, France.
Rev Mal Respir. 2018 Oct;35(8):788-795. doi: 10.1016/j.rmr.2018.06.001. Epub 2018 Aug 31.
Rhinitis and asthma are common diseases that are strongly linked from both the epidemiological and patho-physiological point of view. A precise aetiological diagnosis is required in order to optimize treatment. Nasal provocation tests (NPT) determine precisely the role of the allergen in the initiation of the symptoms of rhinitis particularly when the history does not produce convincing evidence of the clinical relevance of an allergen. It may also have important consequences for the choice of an allergenic immunotherapy. NPT are not standardized but simple methods based on international recommendations provide us with good diagnostic accuracy. In this paper, we will discuss the practical aspects of NPT as well as the clinical or research situations where they may be useful for the respiratory physician.
鼻炎和哮喘是常见疾病,从流行病学和病理生理学角度来看,二者联系紧密。为优化治疗方案,需要进行精确的病因诊断。鼻激发试验(NPT)能准确确定过敏原在鼻炎症状引发过程中的作用,尤其是当病史无法提供令人信服的证据证明某种过敏原与临床相关时。它对变应性免疫治疗的选择也可能产生重要影响。鼻激发试验尚未标准化,但基于国际建议的简单方法能为我们提供良好的诊断准确性。在本文中,我们将讨论鼻激发试验的实际应用,以及它们对呼吸科医生可能有用的临床或研究场景。