Marcel D, Weissmann-Nanopoulos D, Mach E, Pujol J F
Brain Res Bull. 1986 May;16(5):573-96. doi: 10.1016/0361-9230(86)90132-2.
The distribution of benzodiazepine binding sites was analysed in limbic structures of rat brain by quantitative radioautography of brain sections incubated with 3H-flunitrazepam (3H-FLU). Quantitative estimation of the binding parameters was made in each range of postero-anterior sections taken. Distribution of 3H-FLU binding sites was found to be rather homogeneous in most of the structures examined but there were regional differences which resulted from variations in the densities of sites rather than in their affinities. A particular distribution pattern of 3H-FLU binding sites was observed in the cingulate cortex contrasting with the homogeneous postero-anterior distribution measured in other cortical areas in the same slices. A significantly greater density of sites was found in the anterior part of the structure as compared to the posterior part. This difference, which corresponds to a change in the density of sites without alteration of their apparent affinity and occurs at a precise anatomical level, is discussed with reference to the anatomical organization of this brain structure and to its possible functional implications.
通过对用³H-氟硝西泮（³H-FLU）孵育的脑切片进行定量放射自显影，分析了大鼠脑边缘结构中苯二氮䓬结合位点的分布。对所取的每一系列前后位切片的结合参数进行了定量估计。发现在大多数检查的结构中，³H-FLU结合位点的分布相当均匀，但存在区域差异，这些差异是由位点密度的变化而非亲和力的变化导致的。在扣带回皮质中观察到³H-FLU结合位点的一种特殊分布模式，这与同一切片中其他皮质区域测量到的均匀前后位分布形成对比。与后部相比，在该结构的前部发现位点密度明显更高。这种差异对应于位点密度的变化而其表观亲和力未改变，且发生在精确的解剖水平，本文将结合该脑结构的解剖组织及其可能的功能影响进行讨论。
