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蛛网膜下腔和实质内出血是一名新发 1 型糖尿病的青春期前儿童严重糖尿病酮症酸中毒的并发症。

Subarachnoid and parenchymal haemorrhages as a complication of severe diabetic ketoacidosis in a preadolescent with new onset type 1 diabetes.

机构信息

Department of Paediatrics and Child Health, Cork University Hospital, Cork, Ireland.

Department of Intensive Care, Cork University Hospital, Cork, Ireland.

出版信息

Pediatr Diabetes. 2018 Dec;19(8):1487-1491. doi: 10.1111/pedi.12760. Epub 2018 Sep 28.

Abstract

Diabetic ketoacidosis (DKA) is one of the most common causes of morbidity and mortality in new onset type 1 diabetes mellitus (T1DM). Children have a higher rate of neurological complications from DKA when compared to adults. The differential for sudden focal neurological deterioration in the setting of DKA is cerebral oedema followed by ischaemic and haemorrhagic stroke. Spontaneous intracranial haemorrhages can present with non-specific features frequently, for example, impaired consciousness, even when biochemical parameters are improving in the setting of DKA. We report the case of a girl with new onset T1D who presented in severe DKA and subsequently developed intracerebral parenchymal and subarachnoid haemorrhages. Our patient is unique in that no focal neurological or neuropsychological deficits have been found at 1-year follow up, compared to the literature which suggests poor outcomes. Our case contrasts with these previous cases as none of the other case reports demonstrated subarachnoid haemorrhages with survival.

摘要

糖尿病酮症酸中毒(DKA)是新发 1 型糖尿病(T1DM)患者发病率和死亡率的主要原因之一。与成人相比,儿童 DKA 后发生神经并发症的风险更高。DKA 背景下突发局灶性神经功能恶化的鉴别诊断包括脑水肿,其次是缺血性和出血性卒中。自发性颅内出血常表现为非特异性特征,例如意识障碍,即使在 DKA 中生化参数改善的情况下也是如此。我们报告了一例新发 T1D 女孩的病例,她在严重 DKA 后出现颅内实质和蛛网膜下腔出血。与文献中提示预后不良的情况不同,我们的患者在 1 年随访时未发现任何局灶性神经或神经心理学缺陷,这是其独特之处。与这些先前的病例相比,我们的病例有所不同,因为没有其他病例报告显示蛛网膜下腔出血并存活。

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