Department of Nutritional Sciences, Faculty of Human Ecology, Yasuda Women's University , Hiroshima , Japan.
Department of Radiation Epidemiology, Radiation Effects Association , Tokyo , Japan.
Mod Rheumatol. 2019 Sep;29(5):880-884. doi: 10.1080/14397595.2018.1519149. Epub 2018 Oct 5.
To describe recent trends in the prevalence of gout and asymptomatic hyperuricemia regarding urate-lowering treatment (ULT) in Japan. A database of health insurance claims managed by the Japan Medical Data Center was used to estimate the annual prevalence of gout and asymptomatic hyperuricemia during 2010-2014. ULT was evaluated for status of the two diseases during the same period. The significance of time trends was evaluated by Cochrane-Armitage trend test. The prevalence of physician-diagnosed gout in men aged 20-64 years was 1.54% (95% CI: 1.49%-1.58%) in 2010, with a slight but significant ( < 0.001) annual increase, up to 1.66% (95% CI: 1.62%-1.71%) in 2014. In women, gout prevalence was somewhat constant about 0.09% during 2010-2014. Among male patients with gout, 78% received ULT. The prevalence of male patients with asymptomatic hyperuricemia in the same age range, who received ULT, increased significantly from 1.77% (95% CI: 1.72%-1.81%) to 2.14% (95% CI: 2.09%-2.19%) during 2010-2014 ( < 0.001). Gout prevalence in adult men in Japan has increased significantly in recent years. The prevalence of asymptomatic hyperuricemia under ULT has also increased significantly and was higher than that of gout.
描述日本降尿酸治疗（ULT）期间痛风和无症状高尿酸血症的最新流行趋势。使用日本医疗数据中心管理的健康保险索赔数据库来估计 2010-2014 年痛风和无症状高尿酸血症的年患病率。评估同期两种疾病的 ULT 状况。使用 Cochrane-Armitage 趋势检验评估时间趋势的显著性。2010 年，20-64 岁男性经医生诊断的痛风患病率为 1.54%（95%CI：1.49%-1.58%），呈轻微但显著（ < 0.001）的逐年上升趋势，到 2014 年达到 1.66%（95%CI：1.62%-1.71%）。在女性中，2010-2014 年期间痛风患病率保持在 0.09%左右。在患有痛风的男性患者中，78%接受了 ULT。在同一年龄范围内接受 ULT 的男性无症状高尿酸血症患者的患病率从 2010 年的 1.77%（95%CI：1.72%-1.81%）显著增加到 2014 年的 2.14%（95%CI：2.09%-2.19%）（ < 0.001）。近年来，日本成年男性痛风的患病率显著增加。接受 ULT 的无症状高尿酸血症的患病率也显著增加，且高于痛风。
