Department of Orthopedic Surgery, Kamagaya General Hospital , Chiba , Japan.
Institute of Rheumatology, Tokyo Women's Medical University , Tokyo , Japan.
Mod Rheumatol. 2019 Sep;29(5):733-736. doi: 10.1080/14397595.2018.1519146. Epub 2018 Nov 1.
We aimed to determine the prevalence of locomotive syndrome (LS) using the 25-question geriatric locomotive function scale (GLFS-25) and identify factors associated with LS in elderly and younger patients with rheumatoid arthritis (RA). Overall, 390 patients with RA who underwent GLFS-25 measurement, bone mineral density determination, and bioelectrical impedance analysis were enrolled. Factors associated with LS were analyzed by comparing patients with and without LS among both elderly and younger patients with RA. The prevalence of LS was 41.5%, 47.7% and 32.3% in all patients, elderly patients, and younger patients with RA, respectively. Pain visual analog scale (VAS) and Health Assessment Questionnaire Disability Index (HAQ-DI) were associated with LS in both elderly and younger patients. Moreover, in younger patients with RA, disease activity score in 28 joints (DAS28), erythrocyte sedimentation rate (ESR), basal metabolic rate, and legs muscle mass were identified as being associated with LS. This study demonstrated that to prevent LS, we should aim to control pain and maintain a low HAQ-DI in elderly and younger patients with RA, and improve disease activity and maintain a higher basal metabolic rate, and legs muscle mass in younger patients with RA.
我们旨在使用 25 项老年人体能活动功能量表（GLFS-25）来确定运动机能综合征（LS）的患病率，并确定老年和年轻类风湿关节炎（RA）患者中与 LS 相关的因素。共有 390 名接受 GLFS-25 测量、骨密度测定和生物电阻抗分析的 RA 患者被纳入本研究。通过比较老年和年轻 RA 患者中存在和不存在 LS 的患者，分析与 LS 相关的因素。在所有 RA 患者、老年患者和年轻 RA 患者中，LS 的患病率分别为 41.5%、47.7%和 32.3%。疼痛视觉模拟量表（VAS）和健康评估问卷残疾指数（HAQ-DI）与老年和年轻 RA 患者的 LS 相关。此外，在年轻 RA 患者中，28 个关节疾病活动评分（DAS28）、红细胞沉降率（ESR）、基础代谢率和腿部肌肉量与 LS 相关。本研究表明，为了预防 LS，我们应该在老年和年轻 RA 患者中努力控制疼痛和保持较低的 HAQ-DI，在年轻 RA 患者中改善疾病活动并保持较高的基础代谢率和腿部肌肉量。
