Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Departament de Medicina de la UAB, Universitat Autònoma de Barcelona, ES-08003 Barcelona, Spain.
Acta Derm Venereol. 2019 Jan 1;99(1):89-94. doi: 10.2340/00015555-3025.
Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carcinomas). Clinical and histopathological data were registered. The fibrotic reaction pattern was classified as mature, intermediate or immature depending on the presence of keloid-like collagen and myxoid stroma. The immature pattern (areas characterized by myxoid changes with no inflammation) was observed in 18 samples and its presence was significantly associated with immunosuppression, budding, desmoplasia, perineural invasion, anatomic level, tumoural depth and metastatic risk in the multivariate analysis. Our findings suggest that the presence of an immature myxoid fibrotic pattern, which can be easily identified by routine hematoxylin-eosin staining, is strongly associated with metastatic risk.
虽然结缔组织增生与皮肤鳞状细胞癌的不良预后相关，但人们对纤维化模式关注甚少。本研究旨在探讨不同的间质纤维化模式作为转移风险的标志物。我们进行了一项多中心回顾性研究，纳入了 102 例皮肤鳞状细胞癌（52 例非转移性和 50 例转移性癌）。记录了临床和组织病理学数据。根据是否存在瘢痕样胶原和黏液样基质，将纤维反应模式分为成熟型、中间型或未成熟型。在 18 个样本中观察到未成熟模式（以黏液样变化为特征，无炎症的区域），其存在在多变量分析中与免疫抑制、芽生、结缔组织增生、神经周围浸润、解剖水平、肿瘤深度和转移风险显著相关。我们的研究结果表明，未成熟的黏液样纤维性模式的存在，通过常规苏木精-伊红染色很容易识别，与转移风险密切相关。
