囊性纤维化基因座与对氧磷酶基因座之间的连锁关系。
Linkage between the loci for cystic fibrosis and paraoxonase.
作者信息
Schmiegelow K, Eiberg H, Tsui L C, Buchwald M, Phelan P D, Williamson R, Warwick W, Niebuhr E, Mohr J, Schwartz M
出版信息
Clin Genet. 1986 May;29(5):374-7. doi: 10.1111/j.1399-0004.1986.tb00507.x.
In a material of 22 Danish, 26 Canadian, 10 Australian, 5 English and 5 American families with at least 2 children affected with cystic fibrosis (CF) a combined positive LOD score of 3.46 was found for the relationship cystic fibrosis-paraoxonase (PON) at recombination fraction theta = 0.07 in males and theta = 0.13 in females. Assuming a three allele model for PON the LOD score was 4.50 at the same recombination fractions. This confirms our earlier finding of an indication of CF-PON synteny.
在22个丹麦家庭、26个加拿大家庭、10个澳大利亚家庭、5个英国家庭和5个美国家庭的材料中，这些家庭至少有2个孩子患有囊性纤维化（CF），在重组率θ=0.07（男性）和θ=0.13（女性）时，发现囊性纤维化与对氧磷酶（PON）之间的联合阳性连锁值为3.46。假设PON为三等位基因模型，在相同重组率下连锁值为4.50。这证实了我们早期关于CF-PON同线性迹象的发现。
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