三乙锡对成人及脐带血红细胞中酶活性的影响。

Effect of triethyltin on enzyme activity in human adult and cord red cells.

作者信息

Patritti-Laborde N, Lachant N A, Tomoda A, Chan M H, Tanaka K R

出版信息

Enzyme. 1986;35(2):87-95. doi: 10.1159/000469327.

Abstract

Since organotin compounds represent an environmental health hazard, we determined the effect of triethyltin bromide (TTB) on red blood cell (RBC) enzyme activity. TTB produced a concentration-dependent inhibition of hexokinase and pyrimidine 5'-nucleotidase for both adult and cord RBC. D-Glucose, but not ATP or MgCl2, prevented the hexokinase inhibition by TTB. Glucose-6-phosphate dehydrogenase, adenylate kinase, and hypoxanthine-guanine phosphoribosyltransferase were also inhibited by TTB. Cord RBC enzymes were more resistant to the effects of TTB than were adult RBC enzymes. Although TTB is a potent inhibitor of hexokinase, physiologic concentrations of glucose appear to protect the RBC during clinical tin intoxication.

摘要

由于有机锡化合物对环境健康构成危害，我们测定了溴化三乙锡（TTB）对红细胞（RBC）酶活性的影响。TTB对成人和脐带血红细胞的己糖激酶和嘧啶5'-核苷酸酶产生浓度依赖性抑制。D-葡萄糖可防止TTB对己糖激酶的抑制作用，而ATP或MgCl2则不能。葡萄糖-6-磷酸脱氢酶、腺苷酸激酶和次黄嘌呤-鸟嘌呤磷酸核糖转移酶也受到TTB的抑制。脐带血红细胞酶比成人红细胞酶对TTB的作用更具抗性。尽管TTB是己糖激酶的强效抑制剂，但在临床锡中毒期间，生理浓度的葡萄糖似乎可保护红细胞。