Evidence for differing leukotriene receptors in gastric mucosa.

Exogenously administered LTD4 was found to increase pepsin secretion from and decrease the transgastric electrical potential difference across the stomachs of anesthetized cats. The former response was completely blocked by prior administration of a new and selective LTD4 antagonist, L-649,923, while the potential difference response was unaffected. This result, coupled with previous evidence of a difference in leukotriene potency order for the two responses, suggests the presence of functionally different leukotriene receptor subtypes in the gastric mucosa.