The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice.

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作者信息

Rainsford K D

机构信息

Department of Pharmacology, University of Cambridge, England, U.K.

出版信息

Agents Actions. 1987 Aug;21(3-4):316-9. doi: 10.1007/BF01966502.

DOI:10.1007/BF01966502

PMID:3687587

Abstract

摘要

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本文引用的文献

Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents.

Prostaglandins. 1981;21 Suppl:113-8. doi: 10.1016/0090-6980(81)90126-x.

Investigation of the vascular actions of arachidonate lipoxygenase and cyclo-oxygenase products on the isolated perfused stomach of rat and rabbit.

Prostaglandins. 1981 Jul;22(1):141-56. doi: 10.1016/0090-6980(81)90061-7.

Selective inhibitor of slow reacting substance of anaphylaxis.过敏反应迟缓反应物质的选择性抑制剂。

Nat New Biol. 1973 Oct 17;245(146):215-7. doi: 10.1038/newbio245215a0.

LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist.LY171883，1-小于2-羟基-3-丙基-4-小于4-（1H-四氮唑-5-基）丁氧基大于苯基大于乙酮，一种口服活性白三烯D4拮抗剂。

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Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.

J Med Chem. 1986 Aug;29(8):1429-35. doi: 10.1021/jm00158a019.

Selective inhibition of leukotriene C4 synthesis in human neutrophils by ethacrynic acid.

Biochem Biophys Res Commun. 1986 May 29;137(1):195-200. doi: 10.1016/0006-291x(86)91195-2.

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Comparison of the action of cholinomimetics and pentagastrin on gastric secretion in dogs.拟胆碱药与五肽胃泌素对犬胃液分泌作用的比较。

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