手性和结构选择性 MALDI 采用模具基质。
Chirality and structure-selective MALDI using mold matrix.
机构信息
Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo, 192-0379, Japan.
Department of Applied Chemistry, Graduate School of Science and Engineering, Toyo University, 2100 Kujirai, Kawagoe, 350-8585, Japan.
出版信息
Sci Rep. 2018 Sep 3;8(1):13138. doi: 10.1038/s41598-018-31629-6.
A matrix that enabled chirality and structure-selective detection in matrix assisted laser desorption ionization mass spectrometry (MALDI MS) has been developed. Molds of L- or D- alanine were made on a thermoreversible polymer (polyvinyl methyl ether) with 2,4,6-trihydroxyacetophenone, and this was used as a matrix. Separate detection of one optical isomer of alanine was realized in MALDI MS. This technique was also applied to the detection of trisaccharides having the same molecular weight but different structures. Separate detection of raffinose and maltotriose in MALDI MS were presented.
已经开发出一种能够在基质辅助激光解吸电离质谱（MALDI MS）中实现手性和结构选择性检测的基质。使用带有 2,4,6-三羟基苯乙酮的热可逆聚合物（聚乙烯基甲醚）制造 L-或 D-丙氨酸的模具，并将其用作基质。在 MALDI MS 中实现了丙氨酸一种光学异构体的单独检测。该技术还应用于检测具有相同分子量但结构不同的三糖。本文提出了在 MALDI MS 中分别检测棉子糖和麦芽三糖。
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