Ma Lan, Dai Jin, Chen Jie, Cai Hong-Wen, Li Jia-Ying, Li Xin-Yao, Chen Shen-Jie, Mao Wei
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Chin J Integr Med. 2018 Dec;24(12):950-955. doi: 10.1007/s11655-018-2569-2. Epub 2018 Sep 4.
Angiogenesis in atherosclerotic plaque plays a critical role in the mechanism of atherosclerotic physiopathology. Present consensus shows that angiogenesis in atherosclerotic plaque is mainly resulted in hypoxia, inflammation and some pro-angiogenic factors. The homeostasis in plaque, which is hypoxic and infiltrated by inflammatory cells, may lead to angiogenesis, increase the plaque instability and the incidence rate of vascular events. This article reviews the progression of pathogenetic mechanism, physiopathological significance, relevant detecting technique and corresponding therapeutic methods of Chinese and Western medicine of angiogenesis in atherosclerotic plaque, so as to provide more theoretical basis for atherosclerotic clinical treatment.
动脉粥样硬化斑块中的血管生成在动脉粥样硬化病理生理学机制中起关键作用。目前的共识表明，动脉粥样硬化斑块中的血管生成主要由缺氧、炎症和一些促血管生成因子引起。斑块内的稳态处于缺氧状态且有炎症细胞浸润，这可能导致血管生成，增加斑块不稳定性和血管事件的发生率。本文综述了动脉粥样硬化斑块中血管生成的发病机制进展、病理生理意义、相关检测技术以及中西医相应的治疗方法，以期为动脉粥样硬化的临床治疗提供更多理论依据。
