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Delta-sleep-inducing peptide (DSIP) inhibited CRF-induced ACTH secretion from rat anterior pituitary gland in vitro.

作者信息

Okajima T, Hertting G

出版信息

Horm Metab Res. 1986 Jul;18(7):497-9. doi: 10.1055/s-2007-1012357.

DOI:10.1055/s-2007-1012357
PMID:3017833
Abstract

Delta-sleep-inducing peptide (DSIP, 10(-9) - 10(-7) M) significantly inhibited the CRF-induced ACTH release from rat anterior pituitary quarters in vitro. 10(-8) M DSIP showed the most prominent inhibition. DSIP (10(-8) M) also inhibited the CRF-activated cAMP levels in anterior pituitary tissue. DSIP did not influence basal ACTH or cAMP levels. Prostaglandin E2 (PGE2)-release from anterior pituitary quarters was not changed by DSIP. From these results, we conclude that DSIP inhibits CRF-induced ACTH release at the pituitary level through the inhibition of the cAMP system in corticotrophs. The involvement of PGE2 in this phenomenon is unlikely.

摘要

相似文献

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Experientia. 1990 Jan 15;46(1):26-40. doi: 10.1007/BF01955409.