Ahmad Israr, Jafar Tabrez, Mahdi Farzana, Arshad M d, Das Siddharth Kumar, Waliullah Shah, Rizvi Imran, Mahdi Abbas Ali
Indian J Exp Biol. 2016 Nov;54(11):788-93.
Osteoporosis is an important health problem in India owing to the prevalence of vitamin D deficiency across all ages, low level of awareness and higher risk of complications. This disease is characterized by decreased bone mass, bone strength and higher risk of bone fracture. Here, we investigated association between osteocalcin HindIII gene polymorphism and bone mineral density (BMD) in postmenopausal osteoporotic and postmenopausal healthy North Indian women, possibly the first study of this kind in the aforesaid population. We investigated Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) of osteocalcin HindIII in 254 postmenopausal osteoporotic (56.12±7.004 years) and 254 postmenopausal healthy (55.27±5.93 years) North Indian women. BMD at lumbar spine (L1-L4), femoral neck, hip and forearm was measured by dual energy X-ray absorptiometry (DEXA). The results showed no significant correlation between osteocalcin HindIII gene polymorphism and BMD and we conclude that osteocalcin HindIII gene polymorphism may not have major effects on BMD variation in postmenopausal North Indian women.
由于各年龄段维生素D缺乏的普遍存在、认知水平较低以及并发症风险较高，骨质疏松症在印度是一个重要的健康问题。这种疾病的特征是骨量减少、骨强度降低以及骨折风险增加。在此，我们调查了绝经后骨质疏松的北印度女性和绝经后健康的北印度女性中骨钙素HindIII基因多态性与骨密度（BMD）之间的关联，这可能是上述人群中此类研究的首例。我们对254名绝经后骨质疏松的北印度女性（年龄56.12±7.004岁）和254名绝经后健康的北印度女性（年龄55.27±5.93岁）进行了骨钙素HindIII的聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）检测。采用双能X线吸收法（DEXA）测量腰椎（L1-L4）、股骨颈、髋部和前臂的骨密度。结果显示骨钙素HindIII基因多态性与骨密度之间无显著相关性，我们得出结论，骨钙素HindIII基因多态性可能对绝经后北印度女性的骨密度变化没有主要影响。
