Zhou Shan, Huo Da, Goines Sondrica, Yang Tung-Han, Lyu Zhiheng, Zhao Ming, Gilroy Kyle D, Wu Yiren, Hood Zachary D, Xie Minghao, Xia Younan
School of Chemistry and Biochemistry , Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.
The Wallace H. Coulter Department of Biomedical Engineering , Georgia Institute of Technology and Emory University , Atlanta , Georgia 30332 , United States.
J Am Chem Soc. 2018 Sep 26;140(38):11898-11901. doi: 10.1021/jacs.8b06464. Epub 2018 Sep 13.
We report an indirect method for the effective replacement of ligands on the surface of Au nanocrystals with different morphologies. The method involves the deposition of an ultrathin layer of Ag to remove a strong capping agent such as cetyltrimethylammonium chloride (CTAC), followed by selective etching of the Ag layer in the presence of citrate ions as a stabilizer. Using multiple characterization techniques, we confirm that the surface of the Au nanocrystals is covered by citrate ions after the indirect ligand exchange process, and there is essentially no aggregation during the entire process. We also demonstrate that this method is effective in suppressing the toxicity of Au nanospheres by completely replacing the initially used CTAC with citrate.
我们报道了一种间接方法，可有效替换不同形貌的金纳米晶体表面的配体。该方法包括沉积一层超薄银层以去除强封端剂，如十六烷基三甲基氯化铵（CTAC），然后在柠檬酸盐离子作为稳定剂存在的情况下选择性蚀刻银层。通过多种表征技术，我们证实间接配体交换过程后金纳米晶体表面被柠檬酸盐离子覆盖，并且在整个过程中基本没有聚集现象。我们还证明，通过用柠檬酸盐完全取代最初使用的CTAC，该方法可有效抑制金纳米球的毒性。
