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多不饱和脂肪酸的双加氧酶产物的生物学相关性，特别是在血管和大脑中的相关性。

Biological relevance of double lipoxygenase products of polyunsaturated fatty acids, especially within blood vessels and brain.

机构信息

Univ-Lyon, Inserm UMR 1060, Inra UMR 1397 (CarMeN Laboratory), IMBL, INSA-Lyon, Villeurbanne, France.

Univ-Lyon, Inserm UMR 1060, Inra UMR 1397 (CarMeN Laboratory), IMBL, INSA-Lyon, Villeurbanne, France.

出版信息

Biochimie. 2019 Apr;159:55-58. doi: 10.1016/j.biochi.2018.08.009. Epub 2018 Sep 1.

DOI:10.1016/j.biochi.2018.08.009
PMID:30179647
Abstract

The double lipoxygenation of polyunsaturated fatty acids (PUFA) is possible with PUFA having at least three methylene-interrupted double bonds. Several PUFA of the omega-3/n-3 and -6 families may be converted through this route, and the products show interesting inhibitory effects on blood platelet function and cyclooxygenase activities. This review focuses on two main omega-3 PUFA of nutritional interest, namely docosahexaenoic acid (DHA/22:6n-3) and alpha linolenic acid (ALA/18:3n-3). The chemical configuration of the double lipoxygenase end-product from DHA (protectin DX) is compared with that of protectin D1 which is produced through a mono-lipoxygenation step followed by an epoxidation and epoxide hydrolysis process. The different metabolic pathways are discussed as well as the different biological activities of both protectins.

摘要

多不饱和脂肪酸（PUFA）的双加氧作用可能发生在至少具有三个亚甲基中断双键的 PUFA 上。ω-3/n-3 和 -6 家族的几种 PUFA 可以通过这种途径转化，产物对血小板功能和环氧化酶活性表现出有趣的抑制作用。这篇综述主要集中在两种具有营养意义的主要 ω-3 PUFA，即二十二碳六烯酸（DHA/22:6n-3）和α-亚麻酸（ALA/18:3n-3）。DHA（保护素 DX）的双加氧酶终产物的化学结构与通过单加氧作用步骤，然后进行环氧化和环氧化物水解过程产生的保护素 D1 的化学结构进行了比较。讨论了不同的代谢途径以及这两种保护素的不同生物学活性。

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