Department of Neurosurgery, University of Athens, "Evangelismos" Hospital, Athens, Greece; Department of Neuroradiology, University Hospital of Tübingen, Tübingen, Germany.
Department of Radiology, General Anti-Cancer and Oncological Hospital of Athens "St. Savvas", Athens, Greece; Department of Neurosurgery, University of Athens, "Evangelismos" Hospital, Athens, Greece; Department of Neuroradiology, University Hospital of Tübingen, Tübingen, Germany.
J Neuroradiol. 2019 May;46(3):199-206. doi: 10.1016/j.neurad.2018.08.002. Epub 2018 Sep 1.
Evidence of pre-operative resting state functional magnetic resonance (RS-fMRI) validation by correlating it with clinical pre-operative status in brain tumor patients is scarce. Our aim was to validate the functional relevance of RS-fMRI by investigating the association between RS-fMRI and pre-operative motor and language function performance in patients with brain tumor.
Sixty-nine patients with brain tumors were prospectively recruited. Patients with tumors near precentral gyrus (n = 49) underwent assessment for apparent (paresis) and subtle (finger tapping) deficits. Patients with left frontal tumors in the vicinity of the inferior frontal gyrus (n = 29) underwent assessment for gross (aphasia) and mild language (phonological verbal fluency) deficits. RS-fMRI results were extracted by spatial independent component analysis (ICA).
Motor group: paretic patients showed significantly (P = 0.01) decreased BOLD signal in ipsilesional precentral gyrus when compared to contralesional one. Significantly (P < 0.01) lower BOLD signal was also observed in ipsilesional precentral gyrus of paretics when compared with the non-paretics. In asymptomatic patients, a strong positive correlation (r = 0.68, P < 0.01) between ipsilesional motor cortex BOLD signal and contralesional finger tapping performance was observed. Language group: patients with aphasia showed significantly (P = 0.01) decreased RS-fMRI BOLD signal in left BA 44 when compared with non- aphasics. In asymptomatic patients, a strong positive correlation (r = 0.72, P < 0.01) between BA 44 BOLD signal and phonological fluency performance was observed.
Our results showed that RS-fMRI BOLD signal of motor and language networks were significantly affected by the tumors implying the usefulness of the method for assessment of the underlying functions in brain tumors patients.
脑肿瘤患者术前静息态功能磁共振（RS-fMRI）的证据很少通过与临床术前状态相关来验证。我们的目的是通过研究 RS-fMRI 与脑肿瘤患者术前运动和语言功能表现之间的相关性来验证 RS-fMRI 的功能相关性。
前瞻性招募了 69 名脑肿瘤患者。肿瘤靠近中央前回的患者（n=49）接受了明显（瘫痪）和细微（手指敲击）缺陷的评估。肿瘤位于额下回附近左侧额叶的患者（n=29）接受了粗略（失语症）和轻微语言（语音流畅性）缺陷的评估。通过空间独立成分分析（ICA）提取 RS-fMRI 结果。
运动组：与对侧相比，瘫痪患者患侧中央前回的 BOLD 信号明显（P=0.01）降低。与非瘫痪患者相比，瘫痪患者患侧中央前回的 BOLD 信号也明显（P<0.01）降低。在无症状患者中，患侧运动皮层 BOLD 信号与对侧手指敲击表现之间存在强烈的正相关（r=0.68，P<0.01）。语言组：与非失语症患者相比，失语症患者左侧 BA44 的 RS-fMRI BOLD 信号明显（P=0.01）降低。在无症状患者中，BA44 的 BOLD 信号与语音流畅性表现之间存在强烈的正相关（r=0.72，P<0.01）。
我们的结果表明，运动和语言网络的 RS-fMRI BOLD 信号受到肿瘤的显著影响，这表明该方法在评估脑肿瘤患者的潜在功能方面具有实用性。
