School of Pharmacy, University of Otago, Dunedin 9054, New Zealand.
School of Pharmacy, University of Otago, Dunedin 9054, New Zealand.
Int J Pharm. 2018 Oct 25;550(1-2):398-417. doi: 10.1016/j.ijpharm.2018.08.061. Epub 2018 Sep 1.
Tuberculosis (TB) is a major global health burden. The emergence of the human immunodeficiency virus (HIV) epidemic and drug resistance has complicated global TB control. Pulmonary delivery of drugs using dry powder inhalers (DPI) is an emerging approach to treat TB. In comparison with the conventional pulmonary delivery for asthma and chronic obstructive pulmonary disease (COPD), TB requires high dose delivery to the lung. However, high dose delivery depends on the successful design of the inhaler device and the formulation of highly aerosolizable powders. Particle engineering techniques play an important role in the development of high dose dry powder formulations. This review focuses on the development of high dose dry powder formulations for TB treatment with background information on the challenges of the current treatment of TB and the potential for pulmonary delivery. Particle engineering techniques with a particular focus on the spray drying and a summary of the developed dry powder formulations using different techniques are also discussed.
结核病（TB）是全球主要的健康负担之一。人类免疫缺陷病毒（HIV）的出现和耐药性的出现使全球结核病控制变得复杂。使用干粉吸入器（DPI）肺部给药是一种治疗结核病的新方法。与哮喘和慢性阻塞性肺疾病（COPD）的常规肺部给药相比，结核病需要向肺部输送高剂量的药物。然而，高剂量的药物输送取决于吸入器装置的成功设计和高气溶胶化粉末的配方。颗粒工程技术在高剂量干粉配方的开发中起着重要作用。本综述重点介绍了用于结核病治疗的高剂量干粉配方的开发，背景信息是结核病的当前治疗挑战和肺部给药的潜力。颗粒工程技术，特别是喷雾干燥技术，以及使用不同技术开发的干粉配方的总结也进行了讨论。
