Division of Gastroenterology, Saiseikai Karatsu Hospital, Saga, Japan.
Division of Gastroenterology, Saiseikai Karatsu Hospital, Saga,
Digestion. 2019;99(2):172-178. doi: 10.1159/000490889. Epub 2018 Sep 4.
The influence of lifestyle-related factors, including smoking and drinking, was evaluated for Helicobacter pylori eradication therapy with vonoprazan or proton pump inhibitors (PPIs).
Between 2012 and 2016, the medical records of 620 patients receiving H. pylori eradication therapy at Saiseikai Karatsu Hospital were evaluated. Patients had received vonoprazan (20 mg) or PPIs with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 days. The influence of lifestyle-related factors on eradication failure was determined in the 2 groups.
The eradication rates for vonoprazan and lansoprazole, rabeprazole, and esomeprazole were, respectively, 91.0, 73.8, 72.0, and 84.6%. The vonoprazan eradication rate was significantly higher than those for the PPIs (p < 0.01). Habitual smoking and drinking did not increase eradication failure, and smoking and drinking during the eradication period did not reduce the eradication rate. Metabolic syndrome-related factors including obesity, hypertension, and diabetes mellitus had no negative influence on the eradication rate. Eradication with vonoprazan was more effective compared with that achieved through the use of PPIs.
Lifestyle-related factors including smoking and drinking did not exacerbate the H. pylori eradication failure, and vonoprazan was more effective than the PPIs.
评估与生活方式相关的因素（包括吸烟和饮酒）对使用沃诺拉赞或质子泵抑制剂（PPIs）进行幽门螺杆菌根除治疗的影响。
2012 年至 2016 年，对在佐世保市立医院接受幽门螺杆菌根除治疗的 620 例患者的病历进行了评估。患者接受沃诺拉赞（20 mg）或 PPIs（克拉霉素 200 mg 和阿莫西林 750 mg，每日 2 次，共 7 天）治疗。在这 2 组中，确定了生活方式相关因素对根除失败的影响。
沃诺拉赞、兰索拉唑、雷贝拉唑和埃索美拉唑的根除率分别为 91.0%、73.8%、72.0%和 84.6%。沃诺拉赞的根除率明显高于 PPIs（p<0.01）。习惯性吸烟和饮酒并未增加根除失败率，根除期间的吸烟和饮酒也并未降低根除率。肥胖、高血压和糖尿病等代谢综合征相关因素对根除率没有负面影响。与使用 PPIs 相比，沃诺拉赞的根除效果更显著。
与生活方式相关的因素（包括吸烟和饮酒）并未加重幽门螺杆菌的根除失败，并且沃诺拉赞比质子泵抑制剂更有效。
