Department of Cardiology, Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China.
Department of Cardiology, Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China.
Gene. 2018 Oct 30;675:185-190. doi: 10.1016/j.gene.2018.06.107. Epub 2018 Jul 2.
Hypertension is the most important risk factor for cardiovascular and cerebrovascular diseases. The study found that CXCL12 and CNNM2 gene affects the risk of coronary heart disease, but the relationship with hypertension is unclear. The aim of this research is to explore the association between CXCL12 and CNNM2 gene and hypertension in Chinese Han population.
Genotypes at 11 CHD-relevant SNPs were determined in 350 Hypertension patients and 483 controls in Chinese Han population using χ test, genetic model analysis and haplotype analysis.
In the allele model, CXCL12 rs1065297 "G" allele, CXCL12 rs4948878 "G" allele and CXCL12 rs10793538 "T" allele were associated with decreased risk of hypertension (rs1065297: OR = 0.53, p = 0.005; rs4948878: OR = 0.51, p = 0.004; rs10793538: OR = 0.58, p = 0.005). CNNM2 rs12413409 "A" allele and CNNM2 rs11191514 "T" allele were also associated with reduced risk of hypertension (rs12413409: OR = 0.71, p = 0.003; rs11191514: OR = 0.70, p = 0.002). Further stratified analysis by sex and age found that CXCL12, CNNM2 gene also influence the risk of hypertension. Model analysis found that CXCL12 rs1093538 TA-TT genotype was associated with decreased risk of hypertension in the dominant model (OR = 0.57, p = 0.0015); Log-additive model revealed that rs1065297 and rs4948878 in CXCL12 gene have a potential association with essential hypertension (rs1065297: OR = 0.54, p = 0.005; rs4948878: OR = 0.52, p = 0.0038). For CNNM2 gene, rs12413409 GA-AA genotype and rs11191514 CT-TT genotype was associated with reduced risk of hypertension in the dominant model (rs12413409: OR = 0.64, p = 0.012; rs11191514: OR = 0.63, p = 0.0082). CXCL12 "GCGCCGT" and CNNM2 "ATAG" haplotype were associated with reduced risk of hypertension with 0.57-fold and 0.75-fold.
Our analysis suggests that CXCL12, CNNM2 gene influence the risk of hypertension in Chinese Han population.
高血压是心血管和脑血管疾病最重要的危险因素。研究发现，CXCL12 和 CNNM2 基因影响冠心病的风险，但与高血压的关系尚不清楚。本研究旨在探讨 CXCL12 和 CNNM2 基因与中国汉族人群高血压的关系。
采用 χ2 检验、遗传模型分析和单体型分析，在中国汉族人群中检测 350 例高血压患者和 483 例对照者的 11 个 CHD 相关 SNP 的基因型。
在等位基因模型中，CXCL12 rs1065297“G”等位基因、CXCL12 rs4948878“G”等位基因和 CXCL12 rs10793538“T”等位基因与高血压风险降低相关（rs1065297：OR=0.53，p=0.005；rs4948878：OR=0.51，p=0.004；rs10793538：OR=0.58，p=0.005）。CNNM2 rs12413409“A”等位基因和 CNNM2 rs11191514“T”等位基因也与降低高血压风险相关（rs12413409：OR=0.71，p=0.003；rs11191514：OR=0.70，p=0.002）。按性别和年龄进一步分层分析发现，CXCL12、CNNM2 基因也影响高血压的风险。模型分析发现，CXCL12 rs1093538 TA-TT 基因型在显性模型中与降低高血压风险相关（OR=0.57，p=0.0015）；Log-相加模型显示，CXCL12 基因中的 rs1065297 和 rs4948878 与原发性高血压有潜在关联（rs1065297：OR=0.54，p=0.005；rs4948878：OR=0.52，p=0.0038）。对于 CNNM2 基因，rs12413409 GA-AA 基因型和 rs11191514 CT-TT 基因型在显性模型中与降低高血压风险相关（rs12413409：OR=0.64，p=0.012；rs11191514：OR=0.63，p=0.0082）。CXCL12“GCGCCGT”和 CNNM2“ATAG”单体型与降低高血压风险相关，风险比分别为 0.57 倍和 0.75 倍。
我们的分析表明，CXCL12、CNNM2 基因影响中国汉族人群的高血压风险。
