Safigholi Habib, van Veelen Bob, Niatsetski Yury, Song William Y
Department of Electrical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
Elekta Brachytherapy, Veenendaal, The Netherlands.
Brachytherapy. 2018 Nov-Dec;17(6):1030-1036. doi: 10.1016/j.brachy.2018.08.001. Epub 2018 Sep 1.
The direction modulated brachytherapy (DMBT) magnetic resonance-compatible tandem applicator, made from a tungsten alloy rod, has six symmetric peripheral grooves, designed specifically to enhance intensity modulation capacity through achieving directional radiation dose profiles. In this work, the directional dose distributions of the DMBT tandem were modeled and calculated with the Oncentra Brachy advanced collapsed cone engine (ACE), which was validated against Monte Carlo (MC) calculations.
The prototype 3D tandem applicator model was created for use in the Oncentra Brachy treatment planning system. The Ir source was placed inside a DMBT tandem in one and six channels as a single dwell position (DP) per channel with the same index length, as well as 1 DP in a standard tandem. Dose distributions were calculated in a water medium by both ACE and MC and compared.
For 1DP/6DP inside the DMBT and 1DP inside the standard tandem, respectively, the mean dose differences were 3.5/3.3% and <2.8% with the range of 0.1%-6.5%/0.2%-5% and 0.1%-5%, between ACE and MC, respectively.
The DMBT tandem is successfully modeled in a commercial treatment planning system. The ACE algorithm is capable of accurately calculating highly directional dose distributions generated by a dense tungsten alloy contained within the DMBT tandem, with agreements achieved within <3.5%.
由钨合金棒制成的方向调制近距离放射治疗(DMBT)磁共振兼容串联施源器有六个对称的周边凹槽,其专门设计用于通过实现定向辐射剂量分布来增强强度调制能力。在本研究中,使用Oncentra Brachy高级坍缩圆锥引擎(ACE)对DMBT串联施源器的定向剂量分布进行建模和计算,并与蒙特卡罗(MC)计算结果进行验证。
创建了用于Oncentra Brachy治疗计划系统的原型三维串联施源器模型。将铱源放置在DMBT串联施源器的一个和六个通道内,每个通道作为一个驻留位置(DP),具有相同的索引长度,同时在标准串联施源器中设置一个DP。通过ACE和MC在水介质中计算剂量分布并进行比较。
对于DMBT内的1DP/6DP和标准串联施源器内的1DP,ACE与MC之间的平均剂量差异分别为3.5/3.3%和<2.8%,范围分别为0.1%-6.5%/0.2%-5%和0.1%-5%。
DMBT串联施源器在商业治疗计划系统中成功建模。ACE算法能够准确计算由DMBT串联施源器内致密钨合金产生的高度定向剂量分布,一致性在<3.5%以内。