Rubinstein A, Novick B E, Sicklick M J, Bernstein L J, Incefy G S, Naylor P H, Goldstein A L
J Pediatr. 1986 Sep;109(3):422-7. doi: 10.1016/s0022-3476(86)80111-1.
Twenty-five children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex had a characteristic pattern of T cell deficiency. Abnormally low plasma thymulin levels preceded the development of peripheral blood T cell abnormalities. In contrast to patients with congenital T cell deficiencies, our patients had elevated serum levels of thymosin-alpha 1. Treatment with thymosin fraction 5 in three children with AIDS resulted in only transient clinical and immunologic improvement.
25名患有获得性免疫缺陷综合征（艾滋病）或艾滋病相关综合征的儿童呈现出特征性的T细胞缺陷模式。外周血T细胞异常出现之前，血浆胸腺生成素水平异常降低。与先天性T细胞缺陷患者不同，我们的患者血清胸腺素α1水平升高。对3名艾滋病儿童使用胸腺素5组分进行治疗，仅带来了短暂的临床和免疫学改善。
