Centre for Advanced Imaging (CAI), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.
Chem Commun (Camb). 2018 Oct 11;54(82):11538-11541. doi: 10.1039/c8cc05831h.
We report a novel multifunctional hyperbranched polymer based on polyethylene glycol (PEG) as a nanomedicine platform that facilitates longitudinal and quantitative 89Zr-PET imaging, enhancing knowledge of nanomaterial biodistribution and pharmacokinetics/pharmacodynamics both in vivo and ex vivo. Anti-VEGF-A DNA aptamer functionalization increased tumour accumulation by >2-fold in a breast cancer model.
我们报告了一种新型多功能超支化聚合物，以聚乙二醇（PEG）为基础，作为纳米医学平台，促进纵向和定量的 89Zr-PET 成像，增强对纳米材料在体内和体外的生物分布和药代动力学/药效学的了解。抗 VEGF-A DNA 适体功能化使乳腺癌模型中的肿瘤积累增加了超过 2 倍。
