Møller-Larsen A
J Clin Lab Immunol. 1986 Jul;20(3):121-7.
22 healthy individuals with different reactions in humoral and cell-mediated immunity to herpes simplex virus (HSV), as found in complement-fixation, neutralization, and blasttransformation assays have been further investigated using antibody-dependent cell-mediated immunity (ADCC) as a serological test. Sera from all individuals were absorbed on HSV-infected, varicella zoster virus (VZV)-infected or uninfected cell monolayers, before they were used in ADCC with HSV-infected cells, as target. The results with absorbed sera were compared with the results from unabsorbed sera. Fresh uninactivated sera have also been used in some of the investigations. By these experiments a group of individuals was found, who were HSV-positive in ADCC, but negative in all other, above-mentioned tests. Because of these reactions they are proposed to be HSV-positives without a latent infection.
在补体结合、中和及淋巴细胞转化试验中发现，22名对单纯疱疹病毒（HSV）体液免疫和细胞介导免疫反应不同的健康个体，已使用抗体依赖性细胞介导免疫（ADCC）作为血清学检测方法进行了进一步研究。在将所有个体的血清用于以感染HSV的细胞为靶标的ADCC检测之前，先将其吸附于感染HSV、感染水痘带状疱疹病毒（VZV）或未感染的细胞单层上。将吸附后血清的检测结果与未吸附血清的结果进行比较。在一些研究中还使用了新鲜未灭活的血清。通过这些实验，发现了一组个体，他们在ADCC检测中呈HSV阳性，但在上述所有其他检测中均为阴性。由于这些反应，他们被认为是无潜伏感染的HSV阳性个体。
