Andhale Swayamsidha, Goel Harish Chander, Nayak Saispoorthi
Indian J Chest Dis Allied Sci. 2016 Apr-Jun;58(2):103-5.
Objective. To determine the effect of levocetirizine, montelukast and the combination of both the drugs on symptoms of allergic rhinitis. Methods. Seventy-five patients with allergic rhinitis were randomly studied prospectively for a period of two weeks divided into three groups receiving either levocetrizine or montelukast or combination of both. The outcomes were measured by a visual analogue score for nasal and eye symptom during day-time and night-time. Results. All the three regimens were equally effective in improving the day-time symptoms, like sneezing and rhinorrhea. There was also no difference in the control of night-time and eye symptoms among the regimens. Conclusions. Montelukast, levocetirizine and their combination is equally effective in controlling symptoms, of allergic rhinitis. Thus, use of montelukast alone would be cost-effective and do avoid adverse effects of levocetirizine in combination therapy
目的。确定左西替利嗪、孟鲁司特以及两种药物联合使用对过敏性鼻炎症状的影响。方法。前瞻性随机研究75例过敏性鼻炎患者，为期两周，分为三组，分别接受左西替利嗪、孟鲁司特或两者联合治疗。通过日间和夜间鼻及眼症状的视觉模拟评分来衡量结果。结果。所有三种治疗方案在改善日间症状（如打喷嚏和流鼻涕）方面同样有效。各治疗方案在控制夜间症状和眼部症状方面也没有差异。结论。孟鲁司特、左西替利嗪及其联合使用在控制过敏性鼻炎症状方面同样有效。因此，单独使用孟鲁司特具有成本效益，并且可以避免联合治疗中左西替利嗪的不良反应。
