[Stimulation of the reflex response of the anticoagulant system by intermediate product-1 of prothrombin proteolysis].

Injection of the intermediate 1 of prothrombin proteolysis into the frog's systemic circulation mobilized the anticoagulating and the fibrinolytic potential of the organism. This is not so in frogs with destroyed c.n. s. Electrical activity of the carotid chemoreceptors in considerably higher after perfusion with intermediate 1 of the frog's humorally isolated carotid labyrinth, as well as the total coagulation time, the total fibrinolytic activity, and the non-fermentative fibrinolysis in the systematic circulation. The data obtained suggest that the reflex activation of the physiological anticoagulating system can be induced can be induced by intermediate 1 which has the structure similar to thrombin but no clotting activity.