Rehabilitation Medicine, Erasmus MC, , 3000 CA Rotterdam, The Netherlands.
J Rehabil Med. 2018 Sep 28;50(9):821-827. doi: 10.2340/16501977-2375.
Fatigue affects 80% of persons with multiple sclerosis and is associated with daily physical functioning. Both fatigue and physical behaviour are multidimensional concepts.
To study the association between the dimensions of physical behaviour and multiple sclerosis-related fatigue.
Cross-sectional analysis of 212 persons with multiple sclerosis. Participants were severely fatigued, with a Fatigue Severity Scale median (interquartile range): 5.4 (4.8-5.9) and were minimally to moderately neurologically impaired, based on the Expanded Disability Status Scale: 2.5 (2.0-3.5), 73% had relapsing-remitting multiple sclerosis. Fatigue was measured by questionnaires (i.e. Checklist Individual Strength, Modified Fatigue Impact Scale), and the dimensions subjective, physical, cognitive and psychological fatigue were distinguished. Physical behaviour was measured using an Actigraph GT3X+, and outcomes were categorized into the dimensions of activity amount, activity intensity, day pattern, and distribution of activities.
The physical behaviour dimensions were significantly associated with only the physical fatigue dimension (omnibus F-test: 3.96; df1 = 4, df2 = 207; p = 0.004). Additional analysis showed that the amount of activity (unstandardized beta coefficient (β) = -0.16; 95% confidence interval (CI) -0.27 to -0.04; p = 0.007), activity intensity (β = -0.18; 95% CI -0.31 to -0.06; p = 0.004) and day pattern of activity (β = -0.17; 95% CI, -0.28 to -0.06; p = 0.002) were the physical behaviour dimensions that were significantly associated with physical fatigue.
Physical behaviour is weakly associated with physical fatigue and is not associated with other dimensions of fatigue.
疲劳影响 80%的多发性硬化症患者，并与日常身体功能相关。疲劳和身体行为都是多维概念。
研究身体行为维度与多发性硬化症相关疲劳之间的关系。
对 212 名多发性硬化症患者进行横断面分析。参与者存在严重疲劳，疲劳严重程度量表中位数（四分位距）为 5.4（4.8-5.9），扩展残疾状态量表评分最低为 2.0，最高为 3.5，表明存在轻度至中度神经功能障碍，73%的患者为复发缓解型多发性硬化症。疲劳通过问卷（即个体力量检查表、改良疲劳影响量表）进行测量，并区分主观疲劳、身体疲劳、认知疲劳和心理疲劳等维度。身体行为通过 Actigraph GT3X+进行测量，结果分为活动量、活动强度、日间模式和活动分布等维度。
仅身体行为维度与身体疲劳维度显著相关（整体 F 检验：3.96；df1=4，df2=207；p=0.004）。进一步分析显示，活动量（未标准化β系数（β）=-0.16；95%置信区间（CI）-0.27 至-0.04；p=0.007）、活动强度（β=-0.18；95% CI -0.31 至-0.06；p=0.004）和日间活动模式（β=-0.17；95% CI -0.28 至-0.06；p=0.002）是与身体疲劳显著相关的身体行为维度。
身体行为与身体疲劳弱相关，与其他疲劳维度无关。
