Narisawa T, Takahashi M, Masuda T, Niwa M
Gan No Rinsho. 1986 May;32(6):674-9.
It has been clear that the promoting stimulus from bile acids and other colonic constituents play an important role in colon cancer induction in man and in animal models, although essential for the initiation of this cancer probably is relatively week. The level and concentration of bile acids in the colon largely depend on the amount of dietary fat and fiber. High fat diet increases fecal bile acids, and fiber increases the fecal volume and may have a protecting effect through dilution of the bile acids in presenting to the colonic mucosa. It is suggested in animal models that changes of the enterohepatic circulation of bile acids following surgery such as cholecystectomy and right-sided hemicolectomy could provide another cocarcinogenic stimulus or anticarcinogenic mechanism in the development of this cancer.
很明显，胆汁酸和其他结肠成分的促癌刺激在人类和动物模型的结肠癌诱发中起重要作用，尽管对这种癌症的起始而言可能相对较弱。结肠中胆汁酸的水平和浓度在很大程度上取决于饮食中脂肪和纤维的量。高脂肪饮食会增加粪便中的胆汁酸，而纤维会增加粪便体积，并且可能通过稀释胆汁酸与结肠黏膜的接触而起到保护作用。在动物模型中表明，诸如胆囊切除术和右侧半结肠切除术等手术后胆汁酸肝肠循环的改变，可能在这种癌症的发展中提供另一种促癌刺激或抗癌机制。
