Predictive Value of Lipid Accumulation Product, Fatty Liver Index, Visceral Adiposity Index for Metabolic Syndrome According to Menopausal Status.

BACKGROUND

The aim of this study is to investigate the value of clinical indicators of metabolic syndrome according to menopausal status in healthy Korean women.

METHODS

The study included 3936 female patients who were managed at Pusan National University Hospital Health Promotion Center from 2008 to 2014. Each patient completed self-report questionnaires and underwent personal interviews with a healthcare provider to assess their past medical history such as any previous disease, medication and/or menstrual histories along with the measurement of her current body size. Lipid accumulation product (LAP), fatty liver index (FLI), visceral adiposity index (VAI), other anthropometric measurements, and laboratory results were evaluated regarding the patient's diagnostic status of metabolic syndrome and menopause.

RESULTS

The prevalence of metabolic syndrome was 11.6% and that of premenopausal and postmenopausal group were 7.0% and 14.6%, respectively. By univariate analysis, the area under the curve of the receiver operating characteristic curve of LAP, VAI, and FLI were 0.93, 0.93, and 0.93, respectively, in premenopausal group, and they were decreased in postmenopausal group, with the value of 0.89, 0.89, and 0.88, respectively.

CONCLUSION

This study showed the predictive values of LAP, VAI, and FLI for metabolic syndrome upon the patient's status of menopause-such markers should be carefully applied in women of menopausal transition.