Cotter J, Kaess M, Yung A R
Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.
Department of Child and Adolescent Psychiatry, University of Heidelberg, Heidelberg, Germany.
Ir J Psychol Med. 2015 Mar;32(1):21-30. doi: 10.1017/ipm.2014.74.
We aimed to examine the association between childhood trauma and functional impairment in psychotic disorders, bipolar disorder and borderline personality disorder, to speculate on possible mechanisms that underlie this association and discuss the implications for clinical work.
Narrative review of the peer-reviewed English language literature in the area.
High rates of childhood trauma in psychotic disorders, bipolar disorder and borderline personality disorder were identified. This was associated with impaired social and occupational functioning in both the premorbid and established phases of each of these psychiatric disorders over and above the deficits typically observed in these populations. Possible mechanisms mediating this relationship include neurocognitive deficits, insecure attachment, higher rates of comorbidities and problems with adherence and response to treatment.
Routine clinical inquiry about childhood maltreatment should be adopted within mental health settings. This has potentially important treatment implications for identifying those individuals at elevated risk of functional disability. While there is no clear guidance currently available on how to target childhood trauma in the treatment of psychotic disorders, bipolar disorder or borderline personality disorder, there are several promising lines of enquiry and further research is warranted.
我们旨在研究童年创伤与精神分裂症、双相情感障碍和边缘型人格障碍中的功能损害之间的关联,推测这种关联背后的可能机制,并讨论其对临床工作的启示。
对该领域经同行评审的英文文献进行叙述性综述。
在精神分裂症、双相情感障碍和边缘型人格障碍中发现童年创伤发生率很高。这与这些精神疾病的病前和发病阶段的社会和职业功能受损有关,超出了这些人群通常观察到的缺陷。介导这种关系的可能机制包括神经认知缺陷、不安全依恋、更高的共病率以及依从性和治疗反应问题。
心理健康机构应开展关于童年虐待的常规临床询问。这对于识别功能残疾风险较高的个体可能具有重要的治疗意义。虽然目前对于如何在精神分裂症、双相情感障碍或边缘型人格障碍的治疗中针对童年创伤尚无明确指导,但有几条有前景的研究方向,值得进一步研究。