Hatano Keiko, Matsumoto Hideyuki, Mitsutake Akihiko, Yoshimura Junko, Nomura Aya, Imakado Sumihisa, Takahashi Yukitoshi, Hashida Hideji
Department of Neurology, Japanese Red Cross Medical Center, Tokyo, Japan.
Department of Dermatology, Japanese Red Cross Medical Center, Tokyo, Japan.
Case Rep Neurol. 2018 Aug 3;10(2):207-212. doi: 10.1159/000491690. eCollection 2018 May-Aug.
We report on a 44-year-old woman who was diagnosed with toxic epidermal necrolysis (TEN) during the recovery phase from autoimmune limbic encephalitis with anti-glutamate receptor antibodies. Both, autoimmune limbic encephalitis and TEN are very rare diseases. The co-existence of the two diseases has not yet been reported. We speculate that the total of 18 drugs needed for the treatment of encephalitis might have increased the risk of TEN. Similar reports would be required to elucidate the pathophysiology of the co-existence.
我们报告了一名44岁女性，她在患有抗谷氨酸受体抗体的自身免疫性边缘叶脑炎恢复期被诊断出患有中毒性表皮坏死松解症（TEN）。自身免疫性边缘叶脑炎和TEN都是非常罕见的疾病。这两种疾病并存的情况尚未见报道。我们推测，治疗脑炎所需的总共18种药物可能增加了发生TEN的风险。需要更多类似报告来阐明两者并存的病理生理学机制。
