Kwok Wang Chun, Tam Terence Chi Chun, Lam David Chi Leung
Department of Medicine Queen Mary Hospital Hong Kong China.
Respirol Case Rep. 2018 Aug 31;6(7):e00360. doi: 10.1002/rcr2.360. eCollection 2018 Oct.
We report the first case of toxic megacolon associated with afatinib use, which is a potentially fatal complication, with risks of colonic perforation. In this case, the condition improved on stopping afatnib. Clinicians need to be alert of this rare but fatal adverse effect and to avoid anti-diarrhoeal agents, which can worsen toxic megacolon. Anti-diarrhoeal agents are routinely given if diarrhoea occurs on afatinib. These should be stopped and avoided if toxic megacolon occurs.
我们报告了首例与使用阿法替尼相关的中毒性巨结肠病例，这是一种潜在的致命并发症，存在结肠穿孔风险。在此病例中，停用阿法替尼后病情有所改善。临床医生需要警惕这种罕见但致命的不良反应，并避免使用止泻剂，因为止泻剂会使中毒性巨结肠恶化。如果在使用阿法替尼时出现腹泻，通常会给予止泻剂。如果发生中毒性巨结肠，应停用并避免使用这些药物。
