Kaku K, Tsuchiya M, Tanizawa Y, Okuya S, Inoue Y, Kaneko T, Yanaihara N
Peptides. 1986;7 Suppl 1:193-5. doi: 10.1016/0196-9781(86)90185-3.
VIP content in the rat pineal gland and cyclic AMP accumulation in response to VIP in the daily light and dark cycle were examined. VIP content in the pineal varied significantly during the day and night; the content decreased during exposure to light and was lowest at the onset of darkness, 6 p.m. (mean +/- SE, 23 +/- 5 pg/pineal), and increased during the night and was highest at the onset of light, 6 a.m. (72 +/- 12 pg/pineal). Response of cyclic AMP accumulation to VIP varied with a periodicity inversely related to the daily light and dark cycle of VIP content; cyclic AMP accumulation in response to 10(-7) M VIP increased in proportion to periods of exposure to light and peaked at 6 p.m., and decreased with the onset of darkness.
研究了大鼠松果体中的血管活性肠肽（VIP）含量以及在昼夜光照周期中对VIP的环磷酸腺苷（cAMP）积累情况。松果体中的VIP含量在白天和夜晚有显著变化；光照期间含量下降，在傍晚6点黑暗开始时最低（平均值±标准误，23±5 pg/松果体），夜间含量增加，在清晨6点光照开始时最高（72±12 pg/松果体）。cAMP积累对VIP的反应具有与VIP含量的昼夜光照周期呈反比的周期性变化；对10^(-7) M VIP的cAMP积累随光照暴露时间成比例增加，并在下午6点达到峰值，随着黑暗开始而下降。
