粘毛山龙眼中的两种新的24-降齐墩果烷三萜—— vistriterpenoids A和B
Vistriterpenoids A and B, Two New 24-Nor-oleanane Triterpenoids from Dodonaea viscosa.
作者信息
Wang Xiao-Hang, Zhu Ke-Xin, Li Jing-Ya, Lei Chun, Hou Ai-Jun
机构信息
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, P. R. China.
出版信息
Chem Biodivers. 2018 Nov;15(11):e1800426. doi: 10.1002/cbdv.201800426. Epub 2018 Oct 31.
Two new triterpenoids, vistriterpenoids A (1) and B (2), and four known ones, were acquired from Dodonaea viscosa. Compounds 1 and 2 represent the 24-nor-oleanane triterpenoids isolated from the genus Dodonaea for the first time. Their structures were identified based on extensive spectroscopic methods. Compounds 1, 2, 5, and 6 exerted inhibitory activities against PTP1B in vitro.
从坡柳中获得了两种新的三萜类化合物，即vistriterpenoids A（1）和B（2），以及四种已知的三萜类化合物。化合物1和2是首次从坡柳属植物中分离得到的24-降齐墩果烷型三萜类化合物。它们的结构通过广泛的光谱方法得以确定。化合物1、2、5和6在体外对蛋白酪氨酸磷酸酶1B（PTP1B）具有抑制活性。
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