Kraus Christina N, Sodha Pooja, Vaidyanathan Priya, Kirkorian A Yasmine
Department of Dermatology, University of California, Irvine, California.
Department of Dermatology, Duke University, Durham, North Carolina.
Pediatr Dermatol. 2018 Nov;35(6):e371-e374. doi: 10.1111/pde.13670. Epub 2018 Sep 6.
The extrathyroid manifestations of Graves disease (GD) include thyroid orbitopathy, dermopathy, and acropachy. Thyroid dermopathy (TD), also known as pretibial myxedema, classically presents as nonpitting edema or plaquelike lesions on the pretibial region, while thyroid acropachy (TA) is seen in cases of severe TD, characterized by soft tissue swelling and clubbing of fingers and toes, as well as a periosteal reaction of the bones of the hands and feet. Both TD and TA are rare manifestations of thyroid disease and uncommonly reported in pediatric patients. Our aim was to increase awareness of dermatological manifestations associated with pediatric GD and review the literature of pediatric thyroid dermopathy as well as report a case of acropachy in a child.
格雷夫斯病(GD)的甲状腺外表现包括甲状腺眼病、皮肤病变和指端粗厚。甲状腺皮肤病变(TD),也称为胫前黏液性水肿,典型表现为胫前区域的非凹陷性水肿或斑块样病变,而甲状腺指端粗厚(TA)见于严重TD病例,其特征为软组织肿胀、手指和脚趾杵状变,以及手足骨骼的骨膜反应。TD和TA都是甲状腺疾病的罕见表现,在儿科患者中鲜有报道。我们的目的是提高对儿科GD相关皮肤表现的认识,回顾儿科甲状腺皮肤病变的文献,并报告一例儿童指端粗厚病例。