Jakoubek B, Sumová A, Kosar E, Dĕdicová A
Physiol Bohemoslov. 1986;35(3):269-75.
Repeated, thirty minute anticipation of unavoidable painful stimulation causes endorphin-induced analgesia in rats. This type of stress-induced analgesia (SIA) develops rapidly during the first minutes of the exposure to anticipation stress. SIA can be demonstrated during the whole period of anticipation stress. Ergot drugs (DH--ergotoxine, lisuride, trans-9,10 dihydrolisuride) administered 30 min before the onset of anticipation stress, blocked completely this form of SIA. On the other hand, no effect of ergot alkaloids in the tail-flick latency, as measured under resting conditions, was observed. Possible interactions of ergot alkaloids with opiate receptors as an important mechanism by which ergot drugs affect SIA are discussed.
反复30分钟预期不可避免的疼痛刺激会导致大鼠体内内啡肽诱导的镇痛作用。这种类型的应激诱导镇痛（SIA）在暴露于预期应激的最初几分钟内迅速形成。在整个预期应激期间都可以证明SIA的存在。在预期应激开始前30分钟给予麦角药物（DH - 麦角毒碱、利苏瑞肽、反式 - 9,10 - 二氢利苏瑞肽），可完全阻断这种形式的SIA。另一方面，在静息条件下测量时，未观察到麦角生物碱对甩尾潜伏期有影响。文中讨论了麦角生物碱与阿片受体的可能相互作用，这是麦角药物影响SIA的重要机制。
