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骨嗜酸性肉芽肿。15例报告,其中10例存活,平均随访4年(作者译)

[Eosinophil granuloma of bones. Report of 15 cases including 10 survivals with an average follow up of 4 years (author's transl)].

作者信息

Augereau B, Thuilleux G, Moinet P

出版信息

J Chir (Paris). 1977;113(2):159-70.

PMID:301883
Abstract

The bony form of eosinophil granuloma in histocytosis X, raises diagnostic and prognostic problems for the surgeon. 15 cases are reported here which permitted the authors to perform a rapid general review of this disease and judge its course as 10 patients were followed up with a minimum follow up period of 4 years. These observations confirm: --that the local course is always spontaneously favourable: --that the risk of a passage from an extra-bony form of histiocytosis X, should be considered all the more serious when the subject is younger, when there exist certain localisations, such as the mastoid, where there are certain general clinical signs or biological disturbances. Apart from exceptional symptomatic treatment, such as spinal decompression or treatment of a spontaneous fracture, the essential stage of clinical examination is biopsy. Medical treatments do not seem to have any influence on the bony lesion and are not without risk (radiotherapy). Although depending on various criteria, the prognosis should always be reserved and the patient should be followed up for a long period.

摘要

组织细胞增多症X中嗜酸性粒细胞肉芽肿的骨质形态,给外科医生带来了诊断和预后方面的问题。本文报告了15例病例,使作者能够对该疾病进行快速全面的回顾,并判断其病程,因为对10例患者进行了随访,最短随访期为4年。这些观察结果证实:——局部病程总是自发好转;——当患者年龄较小、存在某些特定部位(如乳突)、有某些全身临床体征或生物学紊乱时,组织细胞增多症X从骨外型转变的风险应被视为更为严重。除了特殊的对症治疗,如脊髓减压或自发性骨折的治疗外,临床检查的关键阶段是活检。药物治疗似乎对骨病变没有任何影响,而且并非没有风险(放疗)。尽管预后取决于各种标准,但始终应持保留态度,并且应对患者进行长期随访。

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