a University of Hawaii Cancer Center.
b Graduate Program of Molecular Biosciences and Bioengineering , University of Hawaii , Honolulu , Hawaii , USA.
Cancer Biol Ther. 2019;20(1):1-5. doi: 10.1080/15384047.2018.1507259. Epub 2018 Sep 6.
In the past 25 years, incidence rates of breast cancer have risen about 30% in westernized countries. Mutations in BRCA1 and BRCA2 are the most prominent cause of breast cancer. However, these cancer susceptibility genes (BRCAs) only account for a few percent of women suffering breast tumor. With our understanding that BRCAs are Fanconi Anemia (FA) genes, investigations into the FA signaling network should provide a previously unrecognized key to unlock in-depth insights into both etiology and treatment of breast cancer. Here, we discuss utilization of the FA signaling as a unique genetic model system to expand our knowledge about the molecular biology of breast cancer and potential applications of the gained knowledge to enable preventive and therapeutic approaches for breast cancer patient care.
在过去的 25 年中，西方化国家的乳腺癌发病率上升了约 30%。BRCA1 和 BRCA2 的突变是乳腺癌的最主要原因。然而，这些癌症易感基因（BRCAs）只占患有乳腺肿瘤的女性的少数。由于我们知道 BRCAs 是范可尼贫血（FA）基因，因此对 FA 信号网络的研究应该为深入了解乳腺癌的病因和治疗提供以前未被认识到的关键。在这里，我们讨论了利用 FA 信号作为独特的遗传模型系统来扩展我们对乳腺癌分子生物学的认识，以及将获得的知识应用于为乳腺癌患者护理提供预防性和治疗性方法的潜力。
