阅读障碍儿童、注意力缺陷多动障碍（ADHD）儿童以及合并阅读障碍/ADHD儿童之间的全脑灰质形态测量差异。
Global gray matter morphometry differences between children with reading disability, ADHD, and comorbid reading disability/ADHD.
作者信息
Jagger-Rickels Audreyana C, Kibby Michelle Y, Constance Jordan M
机构信息
Southern Illinois University, Carbondale, United States.
Southern Illinois University, Carbondale, United States.
出版信息
Brain Lang. 2018 Oct;185:54-66. doi: 10.1016/j.bandl.2018.08.004. Epub 2018 Sep 4.
Abstract
Extensive, yet disparate, research exists elucidating structural anomalies in individuals with Reading Disability (RD) or ADHD. Despite ADHD and RD being highly comorbid, minimal research has attempted to determine shared patterns of morphometry between these disorders. In addition, there is no published research examining the morphometry of comorbid RD and ADHD (RD/ADHD). Hence, we conducted voxel-based morphometry on the MRI scans of 106 children, ages 8-12 years, with RD, ADHD, or RD/ADHD, and typically developing controls. We found right caudate and superior frontal regions in both RD and ADHD, along with areas specific to RD and to ADHD that are consistent with current theories on these disorders. Perhaps most importantly, we found a potential neurobiological substrate for RD/ADHD. Further, our findings illustrate both shared and specific contributors to RD/ADHD, supporting two current theories on the comorbidity of RD and ADHD, thereby facilitating future work on potential etiologies of RD/ADHD.
摘要
已有大量但分散的研究阐明了患有阅读障碍（RD）或注意力缺陷多动障碍（ADHD）个体的结构异常情况。尽管ADHD和RD高度共病，但极少有研究试图确定这两种疾病之间形态测量学的共同模式。此外，尚无已发表的研究对共病的RD和ADHD（RD/ADHD）的形态测量学进行考察。因此，我们对106名8至12岁患有RD、ADHD或RD/ADHD的儿童以及发育正常的对照组儿童的MRI扫描图像进行了基于体素的形态测量学研究。我们发现RD和ADHD患者的右侧尾状核及额上回区域，以及与这些疾病当前理论相符的RD和ADHD各自特有的区域。也许最重要的是，我们发现了RD/ADHD潜在的神经生物学基础。此外，我们的研究结果阐明了对RD/ADHD既有共同作用也有特定作用的因素，支持了目前关于RD和ADHD共病的两种理论，从而有助于未来对RD/ADHD潜在病因的研究。
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