Gajdziok Jan
Ceska Slov Farm. 2018 Summer;67(2):59-65.
Disintegrants are substances which promote disintegration of the solid dosage form in the dissolution medium or body fluids. Efficient disintegration is an important prerequisite for ensuring release of the active substance and its good bioavailability. Several mechanisms of disintegrants´ action are currently recognized, but disintegration is a complex process, and the majority of substances act by combining multiple mechanisms. Superdisintegrants as an innovative materials allow more efficient disintegration of the dosage form in lower concentrations, without any negative impact on processability and mechanical properties of the final dosage form. Currently are in pharmaceutical technology used synthetic, modified (semi-synthetic), and also natural superdisintegrants, whose main representatives discribes this article. Key words: disintegrants • superdisintegrants • solid dosage forms • tablets • disintegration time • excipients.
崩解剂是能促进固体剂型在溶出介质或体液中崩解的物质。有效的崩解是确保活性物质释放及其良好生物利用度的重要前提。目前已认识到崩解剂作用的几种机制，但崩解是一个复杂的过程，大多数物质通过多种机制共同作用。超级崩解剂作为一种创新材料，能在较低浓度下更有效地使剂型崩解，且对最终剂型的加工性能和机械性能没有任何负面影响。目前在制药技术中使用的有合成的、改性（半合成）的以及天然超级崩解剂，本文将介绍其主要代表。关键词：崩解剂•超级崩解剂•固体剂型•片剂•崩解时间•辅料
