Simonazzi Analía, Cid Alicia Graciela, Paredes Alejandro Javier, Schofs Laureano, Gonzo Elio Emilio, Palma Santiago Daniel, Bermúdez José María
Instituto de Investigaciones para la Industria Química, Universidad Nacional de Salta - Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta 4400, Argentina.
Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, Universidad Nacional de Córdoba - Consejo Nacional de Investigaciones Científicas y Técnicas, Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba 5000, Argentina.
Ther Deliv. 2018 Sep;9(9):623-638. doi: 10.4155/tde-2018-0037.
Solid dispersions using Poloxamer 407 as carrier were developed to improve albendazole (ABZ) solubility and dissolution profiles.
ABZ/poloxamer solid dispersions were prepared, and dissolution profiles were mathematically modeled and compared with physical mixtures, pharmaceutical ABZ and a commercial formulation.
Poloxamer 407 increased exponentially ABZ solubility, in about 400% when 95% w/w of polymer compared with its absence. Solid dispersions initial dissolution rate was three to 20-fold higher than physical mixtures, the drug and the commercial formulation. All the solid dispersions required less than 2.2 min to reach an 80% of ABZ dissolution, while the commercial formulation needed around 40 min.
Solid dispersions improved ABZ solubility and dissolution rate, which could result in a faster absorption and an increased bioavailability.
开发以泊洛沙姆407为载体的固体分散体，以改善阿苯达唑（ABZ）的溶解度和溶出曲线。
制备ABZ/泊洛沙姆固体分散体，并对溶出曲线进行数学建模，与物理混合物、药用ABZ和市售制剂进行比较。
泊洛沙姆407使ABZ溶解度呈指数增加，与无聚合物时相比，当聚合物含量为95%（w/w）时，溶解度增加约400%。固体分散体的初始溶出速率比物理混合物、药物和市售制剂高3至20倍。所有固体分散体达到80% ABZ溶出所需时间少于2.2分钟，而市售制剂需要约40分钟。
固体分散体改善了ABZ的溶解度和溶出速率，这可能导致更快的吸收和提高生物利用度。
