Urandur Sandeep, Marwaha Disha, Gautam Shalini, Banala Venkatesh T, Sharma Madhu, Mishra Prabhat R
Division of Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, India.
Ther Deliv. 2018 Sep;9(9):667-689. doi: 10.4155/tde-2018-0038.
The aim of this article is to collate the recent developments in the field of drug delivery, medical therapeutics and diagnostics specifically involving the nonlamellar liquid crystalline (NLC) systems. This review highlights different NLC phases having cubic, hexagonal and sponge internal structures, and their application in the field of drug delivery, such as dose reduction, toxicity reduction and therapeutic efficacy enhancement either in the form of nanoparticles, colloidal dispersion or gels. In addition, application of NLC systems as vehicles for peptides, proteins and as a theranostic system in cancer and other disease conditions is also elaborated, which is a growing platform of interest. Overall, the present review gives us a complete outlook on applications of NLC systems in the field of medicine.
本文旨在整理药物递送、医学治疗和诊断领域的最新进展，特别是涉及非层状液晶（NLC）系统的进展。本综述重点介绍了具有立方、六方和海绵状内部结构的不同NLC相，及其在药物递送领域的应用，如以纳米颗粒、胶体分散体或凝胶形式实现剂量减少、毒性降低和治疗效果增强。此外，还阐述了NLC系统作为肽、蛋白质载体以及作为癌症和其他疾病状况下的治疗诊断系统的应用，这是一个日益受到关注的平台。总体而言，本综述让我们全面了解了NLC系统在医学领域的应用。
